Abstract In this study, a series of 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazoles (5a–t) were synthesized by condensing 4-amino-3-mercapto-(4 H)-1, 2, 4-triazoles (4a–c) with different aromatic or aroyl acids through one-pot reaction. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation actions. Some of the newly synthesized compounds showed very good anti-inflammatory activity ...
