Synlett

Sultam thioureas: Synthesis and antiviral activity against West Nile virus

…, MG Epstein, JV Pagano, AC Abbene, EB Graham…

Index: Feeny, Rachel M.; Le, Diane N.; Parks, Joseph W.; Epstein, Mark G.; Pagano, Joseph V.; Abbene, Albert C.; Graham, Elaina B.; Farrell, Joanna R.; McGuire, Jason R.; Zoellner, Robert W.; Valente, Edward J.; Barklis, Eric; Wood, Warren J. L. Synlett, 2012 , # 2 p. 301 - 305

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Citation Number: 2

Abstract

Abstract The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X- ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.