Chemistry–An Asian Journal

Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl??Containing 1??Alkanols by Zirconium??Catalyzed Asymmetric Carboalumination of Alkenes and …

S Xu, CT Lee, G Wang, E Negishi

Index: Xu, Shiqing; Lee, Ching-Tien; Wang, Guangwei; Negishi, Ei-Ichi Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1829 - 1835

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Citation Number: 18

Abstract

Abstract A highly enantioselective and widely applicable method for the synthesis of various chiral 2-alkyl-1-alkanols, especially those of feeble chirality, has been developed. It consists of zirconium-catalyzed asymmetric carboalumination of alkenes (ZACA), lipase-catalyzed acetylation, and palladium-or copper-catalyzed cross-coupling. By virtue of the high selectivity factor (E) associated with iodine, either (S)-or (R)-enantiomer of 3-iodo-2-alkyl-1 ...