Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N (1) triazole, compound 51, was identified as a potent and selective Kv1. 5 inhibitor with an acceptable PK and liability profile.
