Chemical reactivity and skin sensitization potential for benzaldehydes: can schiff base formation explain everything?

…, H Gfeller, T Haupt, G Brunner

Index: Natsch, Andreas; Gfeller, Hans; Haupt, Tina; Brunner, Gerhard Chemical Research in Toxicology, 2012 , vol. 25, # 10 p. 2203 - 2215

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Citation Number: 15

Abstract

Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing chemicals have been divided into applicability domains according to their suspected reaction mechanism. The widely accepted Schiff base applicability domain covers aldehydes and ketones, and detailed structure–activity-modeling for this chemical group was presented. While Schiff base formation is the obvious reaction pathway for these ...