Tetrahedron: Asymmetry

Approach to a better understanding and modeling of (S)-dihydrofuran-2-yl,(S)-tetrahydrofuran-2-yl-, and furan-2-yl-β-dialkylaminoethanol ligands for enantioselective …

C Paolucci, G Rosini

Index: Paolucci, Claudio; Rosini, Goffredo Tetrahedron Asymmetry, 2007 , vol. 18, # 24 p. 2923 - 2946

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Citation Number: 26

Abstract

This paper outlines our efforts to study the influence of an oxygen atom adjacent to the stereogenic center of β-aminoalcohol derivatives used as ligands for catalysts in the asymmetric alkylation of aldehydes. Thirty-four enantiomerically pure (S)-dihydrofuran-2- yl,(S)-tetrahydrofuran-2-yl-, and furan-2-yl-β-dialkylamino alcohols have been prepared from 1, 4: 3, 6-dianhydromannitol, 1, 4: 3, 6-dianhydrosorbitol, and aminoacids, and then have ...