Tetrahedron

Synthesis of substituted asymmetrical biphenyl amino esters as alpha helix mimetics

AB Williams, RN Hanson

Index: Williams, Anna B.; Hanson, Robert N. Tetrahedron, 2012 , vol. 68, # 27-28 p. 5406 - 5414

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Citation Number: 9

Abstract

As part of our ongoing project to develop new molecular probes for estrogen receptor-alpha, we are exploring the utility of internally-substituted asymmetric biphenyls as a proteomimetic scaffold. In this study, we describe synthetic methods for preparing the requisite substituted- bromophenol precursors, their further elaboration, and the subsequent Suzuki–Miyaura coupling of these sterically-hindered and electronically-rich aromatic systems. The results ...