Synthetic ether lipids display a wide range of biological activities including inhibition of (1) membrane-associated enzyme [protein kinase C (PKC), l*” phospholipase C, 2b and sodium/potassium ATPasekY1 activity,(2) neoplastic cell growth! and (3) infectious HIV-1 replicati~ n.~~~ Exact mechanisms of action for these inhibitory activities have not been established, but some interrelationships may occur. Both preferential PKC inhibition1> 2 ...
