Synthesis of 1, 2??Diamino??1, 2??Diphenylbutane by Titanium Induced Reaction of Ammonia with Acetophenone

E Volckaerts, HJ Geise, F Daelemans…

Index: Volckaerts, E.; Geise, H. J.; Daelmans, F.; Claereboudt, J. Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 6 p. 497 - 502

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Abstract

Abstract Reaction at room temperature of gaseous ammonia with acetophenone under the influence of low-valent titanium-prepared from TiCl 3: LiAlH 4 in the molar ratio 2: 1-leads to formation of 2, 3-diamino-2, 3-diphenylbutane in a synthetically useful yield (58%). It is essential to simultaneously add NH 3 and ketone keeping their ratio 1: 1 until the ratio Ti: NH 3: ketone= 1: 1: 1 is reached. Mass spectral characteristics and other spectroscopic ...