Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki–Miyaura cross-coupling

A Junker, D Schepmann, J Yamaguchi…

Index: Organic and Biomolecular Chemistry, , vol. 12, # 1 p. 177 - 186

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Citation Number: 4

Abstract

... Chemistry general. ... of 13 C and 1 H NMR signals were supported by 2D NMR techniques; MS: APCI = atmospheric pressure chemical ionization, EI ... The combined organic layers were washed with water (300 mL) and brine (300 mL), dried (Na 2 SO 4 ) and concentrated in vacuo ...