The total synthesis of hypodematine

ZY Kang, QJ Zhang, RY Chen, PC Zhang…

Index: Kang, Zhi-Yun; Zhang, Qing-Jian; Chen, Ruo-Yun; Zhang, Pei-Cheng; Yu, De-Quan Journal of Asian Natural Products Research, 2013 , vol. 15, # 8 p. 840 - 848

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Abstract

Hypodematine, isolated from Hypodematium sinense Iwatsuki as an alkaloid with a new skeleton, was synthesized via nine reaction steps, in which the synthesis of 2-aryl-1- benzazocines via Beckmann rearrangement of 5 H-benzocyclohepten-5-one oxime mesylate in dry toluene is discussed.