Synlett

N-Boc protection of amines with di-tert-butyldicarbonate in water under neutral conditions in the presence of β-cyclodextrin

MS Reddy, M Narender, YVD Nageswar, KR Rao

Index: Somi Reddy; Narender; Nageswar; Rama Rao Synlett, 2006 , # 7 p. 1110 - 1112

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Citation Number: 25

Abstract

Abstract A new protocol for protection of aryl and aliphatic amines was developed with (Boc) 2 O in the presence of β-cyclodextrin in water. A catalytic amount of β-cyclodextrin is specific for activation of amines. This procedure works well on a wide variety of both electron-rich and electron-deficient amines.

~74%

~89%

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