Inhibition of plasma cholinesterase by O-alkylfluorophosphonates

J Cabal, J Kassa, J Patočka

Index: Cabal, Jiri; Kassa, Jiri; Patocka, Jiri Collection of Czechoslovak Chemical Communications, 1997 , vol. 62, # 3 p. 521 - 526

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Citation Number: 6

Abstract

Abstract Inhibition of plasma cholinesterase by three methylfluorophosphonates (MFF), sarin, soman and cyclosin, and by the products of their hydrolysis and alcoholysis was examined. Inhibition by phosphonic acids and by methyl esters derived from MFF was purely competitive while that by MFF was irreversible. The rate of phosphorylation of cholinesterase by MFF differs, depending on the structure of the alkoxy group in the MFF and decreases ...