Lanthanide-promoted reactions of aldehydes and amine hydrochlorides in aqueous solution. Synthesis of 2, 3-dihydropyridinium and pyridinium derivatives

…, D Chen, J Li, J Ramirez, PG Wang…

Index: Yu, Li-Bing; Chen, Depu; Li, Jun; Ramirez, Johnny; Wang, Peng George; Bott, Simon G. Journal of Organic Chemistry, 1997 , vol. 62, # 1 p. 208 - 211

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Citation Number: 39

Abstract

The chemistry of dihydropyridines has attracted considerable research interest for decades. 1 Dihydropyridines perform important biological function. For example, the reduced form of coenzyme β-nicotinamide adenine dinucleotide (NADH) bears the 1, 4-dihydropyridine moiety. 2 Metabolites of 2, 3-dihydropyridine such as N-methyl-4-phenyl-2, 3- dihydropyridinium (MPDP+) display neurotoxicity. 3 Moreover, dihydropyridines have ...