Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2′ substituents

…, RM Klabe, LT Bacheler, S Erickson-Viitanen…

Index: Patel, Mona; Rodgers, James D.; McHugh Jr., Robert J.; Johnson, Barry L.; Cordova, Beverly C.; Klabe, Ronald M.; Bacheler, Lee T.; Erickson-Viitanen, Susan; Soo S, Ko Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 22 p. 3217 - 3220

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Citation Number: 47

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2′ substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063. ... The synthesis and evaluation of cyclic ...