Synthesis of Tri??or Tetrasubstituted Pyrimidine Derivatives through the [5+ 1] Annulation of Enamidines with either N, N??Dimethylformamide Dialkyl Acetals or …

T Sasada, Y Aoki, R Ikeda, N Sakai…

Index: Sasada, Toshiaki; Aoki, Youichi; Ikeda, Reiko; Sakai, Norio; Konakahara, Takeo Chemistry - A European Journal, 2011 , vol. 17, # 34 p. 9385 - 9394

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Citation Number: 13

Abstract

Abstract The [5+ 1] annulation of enamidines, which were prepared from functionalized silanes, organolithium compounds and two nitriles, with N, N-dimethylformamide dialkyl acetals as the C1 unit is described, leading to the synthesis of tri-and tetrasubstituted pyrimidine derivatives under catalyst-and solvent-free reaction conditions. Furthermore, the [5+ 1] annulation of enamidines by using orthoesters as the C1 unit is described, in which ...