Preparation and antidiabetic activity of new substituted 3, 5??diarylpyrazolesulfonylurea derivatives

R Soliman, HM Feid??Allah, SKE Sadany…

Index: Soliman; Feid-Allah; El Sadany; Mohamed Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 606 - 610

Full Text: HTML

Citation Number: 9

Abstract

Abstract Four series of p-(3, 5-diphenylpyrazole-1)-, p-[5-(p-chlorophenyl)-3-phenylpyrazole- 1]-, p-[5-(p-chlorophenyl)-4-hydroxy-3-phenyl-2-pyrazolin-1-yl]-, and p-[5-(p-chlorophenyl)-4- hydroxy-3-phenylpyrazole-1] benzenesulfonylurea derivatives were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent hypoglycemic activity.