Chemistry Letters

SYNTHESIS OF MACROCYCLIC LACTONES APPLYING INTRAMOLECULAR 1, 3-DIPOLAR CYCLOADDITION: SYNTHESIS OF (±)-A26771B

M Asaoka, M Abe, T Mukuta, H Takei

Index: Asaoka, Morio; Abe, Masayoshi; Mukuta, Takashi; Takei, Hisashi Chemistry Letters, 1982 , p. 215 - 218

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Citation Number: 23

Abstract

The intramolecular 1, 3-dipolar cycloaddition of the nitrile oxides derived from ω-nitroalkyl acrylates gave isoxazoline fused macrocyclic lactones. The direction of 1, 3-dipolar cycloaddition is strongly affected by the ring size of forming lactones. Utilizing this method, ...