A novel series of potent and selective small molecule inhibitors of the complement component C1s

NL Subasinghe, F Ali, CR Illig, MJ Rudolph…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3043 - 3047

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Citation Number: 17

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The bromomethylketones required to accesses 3-O-alkyl-containing pyrazoles (50–52) were synthesized via Mitsunobu chemistry according to Scheme 3. 22 The commercially available pyrazole 43 was alkylated under Mitsunobu ...

116344-17-3

1-phenyl-5-prop...

Addition reactions of immonium benzotriazolates to acetyleni...

[Katritzky, Alan R.; Fali, Clara N.; Oniciu, Daniela C. Tetrahedron, 1995 , vol. 51, # 4 p. 1069 - 1076]

Synthesis of 5??substituted 1??aryl??1H??pyrazole??4??aceton...

[Menozzi; Schenone; Mosti; Mattioli Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 997 - 1002]

A novel series of potent and selective small molecule inhibi...

[Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047]

Nonaqueous diazotization of 5??amino??1??aryl??1H??pyrazole?...

[Beck, James R.; Gajewski, Robert P.; Lynch, Michael P.; Wright, Fred L. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 267 - 270]

Addition reactions of immonium benzotriazolates to acetyleni...

[Tetrahedron, , vol. 51, # 4 p. 1069 - 1076]