Synthetic Communications

Ammonium Chloride–Catalyzed One-Pot Synthesis of 4 (3 H)-Quinazolinones Under Solvent-Free Conditions

G Huang, B Liu, M Teng, Y Chen

Index: Huang, Guoli; Liu, Bo; Teng, Mingyu; Chen, Yegao Synthetic Communications, 2014 , vol. 44, # 12 p. 1786 - 1794

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Citation Number: 2

Abstract

Ammonium chloride, which is a very inexpensive and readily available reagent, can efficiently catalyze three-component, one-pot condensation reactions of 2-amino-benzoic acid esters, ortho esters, and aromatic amines to afford the corresponding 4(3H)-quinazolinones in good to excellent yields under solvent-free conditions. ... Ammonium chloride, which is a very inexpensive and readily available reagent, can efficiently catalyze three-component, one-pot condensation ...