Tetrahedron letters

Synthesis of combretastatins A-1 and B-1

K Odlo, J Klaveness, P Rongved, TV Hansen

Index: Odlo, Kristin; Klaveness, Jo; Rongved, Pal; Hansen, Trond Vidar Tetrahedron Letters, 2006 , vol. 47, # 7 p. 1101 - 1103

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Citation Number: 29

Abstract

The combretastatins are a group of antimitotic agents isolated from the bark of an African tree, Combretum caffrum. 1 Biological studies of these compounds have revealed that they are among the most cytotoxic agents tested so far against several cancer cell lines. 2 They share a common binding site on tubulin with several other well-known antimitotic agents such as colchicine, podophyllotoxin, and steganacin. Combretastatins A-1 (1), B-1 (2), and A-4 (3) ...