Tetrahedron letters

Michael addition approach for the synthesis of novel spiro compounds and 2-substituted malonic acid derivatives from Meldrum's acid

MS Chande, RR Khanwelkar

Index: Chande, Madhukar S.; Khanwelkar, Rahul R. Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7787 - 7792

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Citation Number: 27

Abstract

Novel routes for the synthesis of spiro derivatives of Meldrum's acid and 2-substituted malonic acid derivatives have been developed. Meldrum's acid was monoalkylated using a Michael addition reaction. Mono-Michael adducts were then alkylated using substituted haloalkanes, which on condensation gave spiro derivatives of Meldrum's acid. Bis Michael addition of Meldrum's acid with 1, 5-diaryl-1, 4-pentadien-3-one gave directly a spiro ...