Development of Enantioselective Palladium??Catalyzed Alkene Carboalkoxylation Reactions for the Synthesis of Tetrahydrofurans

BA Hopkins, ZJ Garlets, JP Wolfe

Index: Hopkins, Brett A.; Wolfe, John P. Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9886 - 9890 Angewandte Chemie, 2012 , vol. 124, # 39 p. 10024 - 10028

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Abstract

Abstract The Pd-catalyzed coupling of γ-hydroxyalkenes with aryl bromides affords enantiomerically enriched 2-(arylmethyl) tetrahydrofuran derivatives in good yield and up to 96: 4 er This transformation was achieved through the development of a new TADDOL/2- arylcyclohexanol-derived chiral phosphite ligand. The transformations are effective with an array of different aryl bromides, and can be used for the preparation of products bearing ...