Tetrahedron Letters

The reaction of dimethyltitanocene with N-substituted-β-lactams

I Martı́nez, AR Howell

Index: Martinez, Isamir; Howell, Amy R. Tetrahedron Letters, 2000 , vol. 41, # 30 p. 5607 - 5611

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Citation Number: 23

Abstract

2-Methyleneazetidines have been synthesized and isolated by the reaction of β-lactams with dimethyltitanocene, followed by chromatography on deactivated silica. Efficient conversion required that the lactam nitrogen be strongly deactivated. Methyl transfer predominated in