Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human …

VD Handratta, TS Vasaitis, VCO Njar…

Index: Journal of Medicinal Chemistry, , vol. 48, # 8 p. 2972 - 2984

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Citation Number: 211

Abstract

... Journal of Medicinal Chemistry. ... settings in PCA patients. 5 Orchidectomy (either surgical or medical with a GnRH agonist) remains the standard treatment option for most prostate cancer patients. Medical and surgical ...