Synthesis and hydrolytic cleavage of 1-aryl-5-cyano-6-(2-dimethylaminovinyl)-4-oxo (thioxo)-1, 4-dihydropyrimidines

AS Ivanov, NZ Tugusheva, LM Alekseeva…

Index: Ivanov; Tugusheva; Alekseeva; Granik Russian Chemical Bulletin, 2004 ,  vol. 53,  # 4  p. 873 - 881

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Citation Number: 2

Abstract

Abstract 1-Aryl-5-cyano-6-(2-dimethylaminovinyl)-4-oxo-1, 4-dihydropyrimidines and their 4- thioxo analogs, which were prepared in three steps from cyanoacetamide and cyanothioacetamide, respectively, were subjected to hydrolysis. In aqueous AcOH, hydrolysis of N-(dimethylaminomethylene)-2-cyano-5-dimethylamino-2, 4-pentadieneamide derivatives containing amino groups at position 3 afforded formylpyridones. The reaction ...