Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1. 0] hexane-4, 6-dicarboxylate: identification of potent, …

JA Monn, SM Massey, MJ Valli, SS Henry…

Index: Journal of Medicinal Chemistry, , vol. 50, # 2 p. 233 - 240

Full Text: HTML

Citation Number: 51

Abstract

... Journal of Medicinal Chemistry. ... Results. Chemistry. Analogs (−)-10, (+)-11, and (−)-12 were prepared as described in the Scheme from the mGlu2/3 receptor-active (−)-1R,4S,5S,6S enantiomer (−)-3, itself synthesized as previously described. ...

Process development for a key synthetic intermediate of LY21...

[Waser, Mario; Moher, Eric D.; Borders, Sandy S. K.; Hansen, Marvin M.; Hoard, David W.; Laurila, Michael E.; Letourneau, Michael E.; Miller, Richard D.; Phillips, Michael L.; Sullivan, Kevin A.; Ward, Jeffrey A.; Xie, Chaoyu; Bye, Cheryl A.; Leitner, Tanja; Herzog-Krimbacher, Brigitte; Kordian, Marcus; Muellner, Martin Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1266 - 1274]