Synthesis and bronchodilatory activity of new 4-aryl-3, 5-bis-(2-chlorophenyl) carbamoyl-2, 6-dimethyl-1, 4-dihydropyridines and their 1-substituted analogues

T Suresh, SK Swamy, VM Reddy

Index: Suresh; Swamy; Reddy Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 1 p. 115 - 121

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Citation Number: 24

Abstract

Abstract: Thirty five different 4-aryl-1-substituted 2, 6-dimethyl-3, 5-bis-N-[(substituted) carbamoyl] 1, 4-dihydropyridines have been prepared from a three component condensation reaction of N-(2-chlorophenyl)-acetoacetamide; an aromatic aldehyde and a primary amine under four different experimental conditions. Except for conventional, all the experimental conditions are simple, eco-friendly, economical, and the reactions are rapid ...