Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and …

…, PA Sprengeler, BW Phillips, W Moore…

Index: Hirschmann, Ralph; Yager, Kraig M.; Taylor, Carol M.; Witherington, Jason; Sprengeler, Paul A.; Phillips, Barton W.; Moore, William; Smith III, Amos B. Journal of the American Chemical Society, 1997 , vol. 119, # 35 p. 8177 - 8190

Full Text: HTML

Citation Number: 76

Abstract

A series of phosphonochloridates was prepared from the corresponding phosphonate monoesters, and their reactions with alcohols, amines, and the bisnucleophile 4-aminobutan- 1-ol have been investigated using 31P NMR spectroscopy. In the conversion of phosphonate monoesters to phosphonochloridates via the addition of thionyl chloride or oxalyl chloride, pyrophosphonate anhydrides were found to be formed readily as ...