3, 5??Bis (trifluoromethyl) phenyl Sulfones in the Julia–Kocienski Olefination–Application to the Synthesis of Tri??and Tetrasubstituted Olefins

DA Alonso, M Fuensanta…

Index: Alonso, Diego A.; Fuensanta, Monica; Najera, Carmen European Journal of Organic Chemistry, 2006 , # 20 p. 4747 - 4754

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Citation Number: 8

Abstract

Abstract 3, 5-Bis (trifluoromethyl) phenyl (BTFP) sulfones 8a–d are successfully employed in the modified Julia olefination reaction with carbonyl compounds employing phosphazene base P4-tBu at room temp. in THF, affording tri-and tetrasubstituted olefins in good yields. The Julia–Kocienski olefination between primary alkyl BTFP sulfones 8a, b and aromatic and aliphatic ketones affords the corresponding trisubstituted alkenes in good yields and ...