Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman, and UV–Visible Spectroscopic Analysis of a Rieske-Type Demethylase

KD Daughtry, Y Xiao, D Stoner-Ma, E Cho…

Index: Daughtry, Kelly D.; Xiao, Youli; Stoner-Ma, Deborah; Cho, Eunsun; Orville, Allen M.; Liu, Pinghua; Allen, Karen N. Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2823 - 2834

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Citation Number: 24

Abstract

Herein, the structure resulting from in situ turnover in a chemically challenging quaternary ammonium oxidative demethylation reaction was captured via crystallographic analysis and analyzed via single-crystal spectroscopy. Crystal structures were determined for the Rieske- type monooxygenase, stachydrine demethylase, in the unliganded state (at 1.6 Å resolution) and in the product complex (at 2.2 Å resolution). The ligand complex was obtained from ...