Synthesis and Reactions of Ethyl 6-Aryl-3-ethoxy-6-oxo-2, 4-hexadienoates.

…, SM ISLAM, H NISHIOKA, M HATANAKA…

Index: Tanaka; Kawano; Islam; Nishioka; Hatanaka; Ueda Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 885 - 891

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Citation Number: 6

Abstract

Biologically interesting ethyl 6-aryl-3-ethoxy-6-oxo-2, 4-hexadienoates (1) have been prepared by the Witting reaction of [3-(ethoxycarbonyl)-2-ethoxy-2-propenylidene] triphenylphosphoranes (3a and 3b) and-arsorane (3c) with glyoxal monohydrates (5) and by oxidation of 6-aryl-3-ethoxy-6-hydroxy-2, 4-hexadienoate (9) with activated manganese (IV) oxide supported by silica. Reaction of 1a with 3c gave 3-(4-chlorobenzoyl)-1, 2-trans (and ...