Tetrahedron letters

Synthesis of unnatural amino acid derivatives via palladium-catalyzed 1, 4-addition of boronic acids

D Ray, AM Nyong, A Natarajan

Index: Ray, Devalina; Nyong, Abijah M.; Natarajan, Amarnath Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2655 - 2656

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Citation Number: 2

Abstract

Our laboratory is interested in developing small molecule inhibitors of protein-protein interactions. Recent studies showed that the tetrapeptide pSPTF binds the carboxy terminus domains of the early onset breast cancer gene 1 (BRCT-BRCA1) with micromolar affinities. 1 Structural studies show that the phenylalanine residue (F) in pSPTF makes a key hydrophobic contact with the BRCT-BRCA1. 2 To explore this hydrophobic pocket we planned to ...