Bulletin of the Chemical Society of Japan

Synthesis of Proline and 2-Piperidinecarboxylic Acid via Cobalt-Catalyzed Isomerization–Carbonylation of N-Acyl Unsaturated Cyclic Amines

Y Amino, S Nishi, K Izawa

Index: Amino; Nishi; Izawa Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 620 - 623

Full Text: HTML

Citation Number: 20

Abstract

N-Acyl derivatives of proline and 2-piperidinecarboxylic acid (pipecolic acid) were synthesized in moderate yield from N-acyl unsaturated cyclic amines through cobalt- catalyzed isomerization–carboxylation under hydroformylation conditions in the presence of H 2 O. A possible mechanism for the process is discussed which is related to that of the amidocarbonylation (cobalt-catalyzed formation of N-acyl α-amino acid from aldehyde, ...