Tetrahedron letters

An extremely short synthesis of benzoylpyrrole-type calcium channel activators

CR Dalton, JM Kane, D Rampe

Index: Dalton, Christopher R.; Kane, John M.; Rampe, David Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5713 - 5716

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Citation Number: 14

Abstract

Abstract Friedel-Crafts acylation of methyl 2, 5-dimethylpyrrole-3-carboxylate with 2- chloromethylbenzoyl chloride generated the corresponding 4-(2-chloromethylbenzoyl) pyrrole which was reacted in situ with benzene and aluminum chloride to yield the novel calcium channel activator FPL 64176.

Synthesis of FPL 64176 by 1, 3-Dipolar Cycloaddition

[Santiago, Braulio; Dalton, Christopher R.; Huber, Edward W.; Kane, John M. Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4947 - 4950]

Discovery and synthesis of methyl 2, 5-dimethyl-4-[2-(phenyl...

[Baxter; Dixon; Ince; Manners; Teague Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2739 - 2744]