View all references and we wanted to use it as a reference for the biologic testing of our own compounds. The description of the synthesis of the reference compound 8 in the Banyu patent is limited to the last step, a Wittig-Horner reaction between 6-methyl-4-pyrrolidinylpyridine-2- carboxaldehyde 7 and 3-trifluoromethylbenzyldiethylphosphonate. ... In this paper, we describe the complete synthetic sequence leading to compound 8 which may be useful to the ...
