Synthesis of 2-aryl-3-furancarboxylic acids by arylation of 3-furancarboxylic acid

…, M Čakrt, M Dandárová, Z Friedl…

Index: Jurasek, Adolf; Berecinova, Daniela; Cakrt, Miroslav; Dandarova, Miloslava; Friedl, Zdenek; et al. Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 1 p. 215 - 224

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Citation Number: 2

Abstract

Abstract Arylation of 3-furancarboxylic acid (3-FCA) with 4-X-phenyldiazonium chlorides catalyzed by copper dichloride afforded the non-planar 2-(4-X-phenyl)-3-furancarboxylic acids (X= H, CH 3, OCH 3, Cl, Br, NO 2). Arylation of 3-FCA with 2-X-phenyldiazonium chlorides (X= COOCH 3, NO 2) yielded 2-(2-methoxycarbonylphenyl)-3-furancarboxylic acid and a 3: 1 mixture of 2-(2-nitrophenyl)-and 5-(2-nitrophenyl)-3-furancarboxylic acids, ...