3D-QSAR studies of heterocyclic quinones with inhibitory activity on vascular smooth muscle cell proliferation using pharmacophore-based alignment

…, Y Lee, S Park, HJ You, RY Lee, SY Lee, S Choi

Index: Ryu, Chung-Kyu; Lee, Yoonji; Park, Seul-gi; You, Hea-Jung; Lee, Ra-Young; Lee, Seung-Yon; Choi, Sun Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9772 - 9779

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Citation Number: 16

Abstract

The abnormal proliferation and migration of vascular smooth muscle cells (SMCs) play an important role in the pathology of coronary artery atherosclerosis and restenosis following angioplasty. It was reported that some heterocyclic quinone derivatives such as 6-arylamino- quinoxaline-5, 8-diones and 6-arylamino-1H-benzo [d] imidazole-4, 7-diones have inhibitory activity on rat aortic smooth muscle cell (RAoSMC) proliferation. To understand the ...