The Journal of organic chemistry

Solid-phase synthesis of 4 (1 H)-quinolone and pyrimidine derivatives based on a new Scaffold polymer-bound cyclic malonic acid ester

X Huang, Z Liu

Index: Huang, Xian; Liu, Zhanxiang Tetrahedron Letters, 2001 , vol. 42, # 43 p. 7655 - 7657

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Citation Number: 46

Abstract

An efficient method for the preparation of polymer-bound cyclic malonic acid ester starting from Merrifield resin has been developed. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with nucleophilic