A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases

HB Kwon, C Park, KH Jeon, E Lee…

Index: Jeong, Byeong-Seon; Choi, Hoyoung; Thapa, Pritam; Karki, Radha; Lee, Eunyoung; Nam, Jung Min; Na, Younghwa; Ha, Eun-Mi; Kwon, Youngjoo; Lee, Eung-Seok Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 303 - 306

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Citation Number: 15

Abstract

A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14 containing benzo [4, 5] furo [3, 2-b] pyridine core and 15 comprising chromeno [4, 3-b] pyridine core, were synthesized, and their biological activities were evaluated. 3-(4- Phenylbenzo [4, 5] furo [3, 2-b] pyridin-2-yl) phenol (8) was determined to be a nonintercalative topo I and II dual catalytic inhibitor and 3-(4-phenylchromeno [4, 3-b] ...