a-Amino acids have been developed as educts for the preparation of optically pure a-amino aliphatic ketones. The amino group of the L-amino acid was first blocked as a suitable acyl derivative, namely, acetyl, benzoyl, ethoxycarbonyl, or benzenesulfonyl. Then the lithium carboxylate was formed and treated with alkyl-and alkenyllithium or Grignard reagents. Thus butyl, allyl, and vinyl organometallics were added to the lithium carboxylates of~-aN- ...
