Synthesis of 1, 3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase. 2

…, VE Marquez, JA Kelley, JS Driscoll

Index: Liu, Paul S.; Marquez, Victor E.; Kelley, James A.; Driscoll, John S. Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5225 - 5227

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Citation Number: 13

Abstract

Summary: Syntheses of the novel seven-membered-ring (f)-5-hydroxy-2, 3, 4, 5-tetrahydro- lH-l, 3-diazepin-2-one (8) and its lDD-ribofuranosyl nucleosides 4a and 4b have been accomplished by adaptation of the transpositional allylic oxidation procedure following the electrophilic ad-