Monoamine oxidase inhibitors based on 2-, 4-, and 8-substituted quinolines

IN Gracheva, DI Ioffina, AI Tochilkin…

Index: Gracheva, I. N.; Ioffina, D. I; Tochilkin, A. I.; Gorkin, V. Z. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 3 p. 160 - 165 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 3 p. 18 - 21

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Abstract

The search for new selective inhibitors of monoamine oxidase (MAO) among quinoline derivatives has taken on special interest in recent years in connection with the modern achievements in the study of the chemistry of natural modulators of MAO activity [3]. Continuing the work along this line we synthesized compounds in which the quinoline ring is bonded to aralkylamines of various structures, including those containing aromatically ...