Chemistry–A European Journal

Selective N??Alkylation of Amines with Alcohols by Using Non??Metal??Based Acid–Base Cooperative Catalysis

Y Du, S Oishi, S Saito

Index: Du, Ya; Oishi, Shunsuke; Saito, Susumu Chemistry - A European Journal, 2011 , vol. 17, # 44 p. 12262 - 12267

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Citation Number: 21

Abstract

Higher amines are widely used in both the bulk and fine chemical industry for the synthesis of fundamental materials, such as additives, dyes and agrochemicals.[1] Therefore, the development of a selective N-alkylation method that is cost effective, salt free and environmentally benign is of considerable interest. Indeed, reactions involving the N- alkylation of amines with alcohols [2](RÀOH) in place of RÀX, where X denotes halide, ...