Enantioselective Reduction of β??Keto Acids with Engineered Streptomyces coelicolor

KI Booker??Milburn, R Gillan…

Index: Booker-Milburn, Kevin I.; Gillan, Rebecca; Kimberley, Meriel; Taguchi, Takaaki; Ichinose, Koji; Richard Stephenson; Ebizuka, Yutaka; Hopwood, David A. Angewandte Chemie - International Edition, 2005 , vol. 44, # 7 p. 1121 - 1125

Full Text: HTML

Citation Number: 7

Abstract

1121 Angew. Chem. Int. Ed. 2005, 44, 1121–1125 DOI: 10.1002/anie. 200462076 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim actinorhodin (ACT, 1). S. coelicolor is generally regarded as the best genetically characterized of all the streptomycete bacteria. Recently its complete genomic sequence was published.[1] Over the years a clear picture has emerged for the biosynthesis of the skeleton of 1.[2] It is generally accepted that 2 (or ...