Synthesis of a highly potent leukocyte function??associated antigen??1 antagonist and its metabolite labeled with stable isotopes and carbon??14, part 2

…, D Krishnamurthy, CH Senanayake

Index: Latli, Bachir; Hrapchak, Matt; Xu, Yibo; Qiu, Fenghe; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 13 p. 799 - 808

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Citation Number: 1

Abstract

(S)-2-[(R)-7-(3, 5-Dichlorophenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxybenzyl)-6, 7-dihydro- 5H-imidazo [1, 2-a] imidazole-3-sulfonylamino]-proprionamide (1), a potent lymphocyte function-associated antigen-1 antagonist and its sulfonamide metabolite (2) labeled with stable isotopes and carbon-14 were prepared for Drug Metabolism and PharmacoKinetics and other studies. A long linear route was used to prepare [13C2, 2H3]-(1) using [3, 3, 3- ...