Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

…, VM Avery, PJ Scammells, S McGowan

Index: Kannan Sivaraman, Komagal; Paiardini, Alessandro; Sienczyk, Marcin; Ruggeri, Chiara; Oellig, Christine A.; Dalton, John P.; Scammells, Peter J.; Drag, Marcin; McGowan, Sheena Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5213 - 5217

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Citation Number: 9

Abstract

Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a novel mode of action are urgently required. Two Plasmodium falciparum aminopeptidases, Pf A-M1 and Pf A-M17, play crucial roles in the erythrocytic stage of infection and have been validated as ...