The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

SO Ochiana, V Pandarinath, Z Wang, R Kapoor…

Index: Ochiana, Stefan O.; Pandarinath, Vidya; Wang, Zhouxi; Kapoor, Rishika; Ondrechen, Mary Jo; Ruben, Larry; Pollastri, Michael P. European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 777 - 784

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Citation Number: 28

Abstract

New drugs for neglected tropical diseases such as human African trypanosomiasis (HAT) are needed, yet drug discovery efforts are not often focused on this area due to cost. Target repurposing, achieved by the matching of essential parasite enzymes to those human enzymes that have been successfully inhibited by small molecule drugs, provides an attractive means by which new drug optimization programs can be pragmatically initiated. ...