6-(1H-imidazol-1-yl)-7-nitro-2, 3 (1H, 4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non- …

…, H Kubota, M Shimizu-Sasamata…

Index: Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475

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Citation Number: 126

Abstract

30a, be (a) MNOs, H2SO4;(b) Hz, Pd-C;(c) AczO, EtsN, CHCla;(d) HC1;(e)(COOH) z, 4 N HC1;(f) N02BF4, tetramethylene sulfone. acetamide 27a, prepared by a three-step sequence from 25a, was nitrated with nitronium tetrafluoroborate'* in tetramethylene sulfone to give o-nitro acetamide 28a. When we attempted this transformation using" 03 or KN03 in concentrated HzSO4, the reaction did not proceed to completion. Acidic hydrolysis gave ...