Abstract A simplified synthesis of 6-mono and 6, 6′-di-corynomycolate esters of α, α- trehalose, and related compounds, was achieved by coupling the (hydroxyl-protected) acids to the partially trimethylsilylated sugar in the presence of dicyclohexylcarbodiimide and 4- dimethylaminopyridine. As acid reactants,(2-RS, 3-RS)-3-hydroxy-2-tetradecyloctadecanoic acid (dl-corynomycolic acid) and its 2RS, 3SR diastereomer were prepared from methyl ...
